Our objective is to understand the composition and function of proteins expressed in EVs and how they contribute to mechanisms of resistance in prostate cancer.
Throughout my career I have always been interested in mechanisms of RNA processing that become dysregulated in disease and cancer. My project focuses on defining the mechanisms that drive alternative polyadenylation of AR in metastatic prostate cancer to determine specific sequence elements and trans-acting factors that can be targeted for more effective treatment of metastatic prostate cancer in patients.
Yee Lab fett umn. Schwertfeger lab Phone: classite umn. Immunotherapy has shown promise in some solid tumors including breast cancers with high levels of tumor infiltrating lymphocytes TILs. In other cancers, enhancing T cell infiltration into tumors that lack significant levels of TILs enhances responsiveness to immune based therapies TILs.
Therefore, developing approaches to enhance T cell infiltration into primary and metastatic lesions could enhance the percentage of breast cancer patients that respond to immunotherapy.
The signal transducer and activator of transcription STAT protein family regulates gene expression changes related to proliferation, apoptosis, and immune response. STAT3 is a potent oncogene and a promising target for immunotherapy. There is also an increase in immunomodulatory genes. In addition, we see a compensatory increase in an immune checkpoint protein, PD-L1, expressed by tumor cells and macrophages.
We predict that STAT3 inhibition will enhance T cell infiltration into tumors through increased expression of T cell chemokines, although this will not be sufficient to elicit an anti-tumor response due to increased PD-L1 expression. Therefore, we hypothesize that selectively inhibiting STAT3 and PD-L1 will increase recruitment and enhance activation of T cells at the tumor site, and lead to an effective anti-tumor immune response.
Osteosarcoma OSA is an uncommon but devastating bone cancer, typically diagnosed in children and adolescents. Despite aggressive treatment, many affected children develop metastatic disease for which there is no effective therapy.
Research is a primary mission of the Department of Microbiology and Immunology. Through leading-edge research initiatives and collaborative partnerships, our faculty and department researchers are expanding our understanding of microorganisms, disease, and the immune response. Microbiology and immunology provide the building blocks for the treatment of infections and other diseases. The Microbiology, Immunology and Cancer Biology Seminar is presented on Mondays at noon each week during the academic year and is hosted in conjunction with the Center for Immunology.
The Winford P. Larson Lecture is presented annually and is named for the first head of the department. The Greg R. Germaine Frontiers in Science Lecture is presented annually in conjunction with the School of Dentistry.
You are here Home. Brain imaging is one of the most important tools for understanding the workings of the human mind. They will then join top Cognitive Neuroscience labs at UMN to help conduct neuroimaging research on topics that range from basic sensory and motor processes, to addiction research, to problem solving and decision making.
Please check out our website here. Those accepted will spend 10 weeks in the lab of a physician-scientist, have the opportunity to shadow their lab mentor or another physician-scientist in clinical activities, and have regular interactions with current MSTP students.
Learn more about the mentors and their research. The PNI Program is composed of an intensive laboratory-based research experience that entails close interaction with and mentorship by a training program faculty member that focuses on drug abuse research. TREM trains the next generation of faculty through a balanced 3-year postdoctoral training program in both research and teaching. Teacher training is conducted in local community colleges with a historic background of serving underrepresented communities.
Each year six underrepresented minority students are competitively chosen from the community colleges to take part in LSSURP, conducting research under the mentorship of the postdoctoral scholars and TREM research mentors.
Watson Award Dr. How are pro-survival and pro-apoptotic pathways regulated in cancer cells? How does the tumor microenvironment affect tumor progression? How does the inflammatory microenvironment contribute to the promotion and progression of breast cancer? How do brain tumors evade the immune response and what immunotherapy based strategies can be developed to effectively exploit that knowledge?
What role do heat shock proteins play in apoptotic resistance of pancreatic cancer cells? What is the function of O-glycosylated proteins in the invasion and metastasis of carcinomas in an inflammatory environment? Can genetic engineering be used to modify and devise new anti-cancer biological drugs that can serve as an alternative to chemotherapy in cancer patients that become refractory to conventional therapy?
Women's Cancer Research Members of this program work to improve detection, treatment, and prevention of women's cancers to improve outcomes. Research questions asked include: What is the role of the ubiquitin-dependent protein degradation in initiating and sustaining of solid cancers? What mechanisms cause pain in sickle cell disease, and which targets can be focused on to develop novel opioid based analgesics? How do progesterone receptors interact with protein kinase signaling pathways and estrogen receptors in order to drive breast cancer progression towards endocrine resistance?
How does the activation status of the protein synthesis machinery regulate normal and neoplastic cell growth? How do cytochrome epoxygenases promote breast cancer progression and can these mechanisms be targeted for therapy? How do hypoxia and modulation of angiogenesis affect tumor biology? What specific genetic changes drive tumor development? What biomarkers can be identified from ovarian cancer biospecimens that will be specific and sensitive enough to use to screen the general population for ovarian cancer?
How does activation of growth factor receptors affect cancer cell biology? Transplant Biology and Therapy Research Through basic research in stem cell biology and immunology, members of the Transplant Biology and Therapy Program work together to discover new stem cell transplantation therapies and treatments for cancers relating to the blood and bone marrow.
Research questions asked include: What are the similarities and differences between stem cells and cancer cells in terms of cell proliferative capacity and cell metabolism?
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