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Next SlideShares. You are reading a preview. Create your free account to continue reading. Sign Up. Upcoming SlideShare. What to Upload to SlideShare. Embed Size px. Start on. This ion channel is gated by cGMP. In dark, rod cells consist of certain level of cGMP which keep this channel open. Molecular Mechanism involved in vision The signal transduction starts when light falls on rhodopsin. Following events happen during the process of signal transduction in vision.
Step 1 : Rhodopsin is composed of light absorbing pigment cis retinal and covalently attached protein which is known as opsin. When photon is absorbed by rhodopsin, the energy of photon causes conformation change in rhodopsin by converting cis retinal into all-trans retinal.
In dark when no signal is obtained, GDP is bound and all three protein subunits remain bound. When rhodopsin is excited by photon, the rhodopsin interacts with transducin catalyzing the replacement of bound GDP by GTP from cytosol. Step 3 : The next step in signal transduction pathway is activation of cGMP phosphodiesterase. This article provides insights into the natural chemopreventive role of curcumin via cellular transduction pathways and provides an in depth assessment of its physiological activities in the management of diseases.
Abstract Chemoprevention represents one of the most highly effective anti-cancer strategies and is accompanied by minimal secondary effects as compared to conventional chemotherapies.
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